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1

Integrating Genomics into Drug Discovery and Development: Challenges and Aspirations

Raja, Rajiv, Lee, Young S., Streicher, Katie, Conway, James, Wu, Song, Sridhar, Sriram, Kuziora, Mike, Liu, Hao, Higgs, Brandon W., Brohawn, Philip Z., Bais, Carlos, Jallal, Bahija, Ranade, Koustubh

Journal:

Pharmaceutical Medicine

Year:

2017

Language:

english

File:

PDF, 877 KB

english, 2017

2

Type I interferon–inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis

Ronan J. Walsh, Sek Won Kong, Yihong Yao, Bahija Jallal, Peter A. Kiener, Jack L. Pinkus, Alan H. Beggs, Anthony A. Amato, Steven A. Greenberg

Journal:

Arthritis & Rheumatism

Year:

2007

Language:

english

File:

PDF, 639 KB

english, 2007

3

Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles

Mohammad Salajegheh, Jack L. Pinkus, Anthony A. Amato, Chris Morehouse, Bahija Jallal, Yihong Yao, Steven A. Greenberg

Journal:

Year:

2010

Language:

english

File:

PDF, 958 KB

english, 2010

4

A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo

Elizabeth Ward, Nanette Mittereder, Ellen Kuta, Gary P. Sims, Michael A. Bowen, William Dall’Acqua, Thomas Tedder, Peter Kiener, Anthony J. Coyle, Herren Wu, Bahija Jallal, Ronald Herbst

Journal:

British Journal of Haematology

Year:

2011

Language:

english

File:

PDF, 984 KB

english, 2011

5

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Immunogenicity of Biologics

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 737 KB

english, 2017

6

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Protein Therapeutics in Autoimmune and Inflammatory Diseases

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 235 KB

english, 2017

7

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Protein Engineering: Methods and Applications

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 797 KB

english, 2017

8

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Antibody-drug Conjugates (ADCs)

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 1.21 MB

english, 2017

9

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Stability, Formulation, and Delivery of Biopharmaceuticals

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 233 KB

english, 2017

10

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Expression Systems for Recombinant Biopharmaceutical Production by Mammalian Cells in Culture

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 354 KB

english, 2017

11

Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy

Mohammad Salajegheh, Sek Won Kong, Jack L. Pinkus, Ronan J. Walsh, Anne Liao, Remedios Nazareno, Anthony A. Amato, Bryan Krastins, Chris Morehouse, Brandon W. Higgs, Bahija Jallal, Yihong Yao, David A

Journal:

Annals of Neurology

Year:

2010

Language:

english

File:

PDF, 438 KB

english, 2010

12

Neutralization of interferon-α/β–inducible genes and downstream effect in a phase I trial of an anti–interferon-α monoclonal antibody in systemic lupus erythematosus

Yihong Yao, Laura Richman, Brandon W. Higgs, Christopher A. Morehouse, Melissa de los Reyes, Philip Brohawn, Jianliang Zhang, Barbara White, Anthony J. Coyle, Peter A. Kiener, Bahija Jallal

Journal:

Arthritis & Rheumatism

Year:

2009

Language:

english

File:

PDF, 1004 KB

english, 2009

13

Structure-Based design and discovery of novel inhibitors of protein tyrosine phosphatases

Ping Huang, John Ramphal, James Wei, Congxin Liang, Bahija Jallal, Gerald McMahon, Cho Tang

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 658 KB

english, 2003

14

The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120ctn

Holsinger, Leslie J, Ward, Kevin, Duffield, Bill, Zachwieja, Joseph, Jallal, Bahija

Journal:

Year:

2002

Language:

english

File:

PDF, 398 KB

english, 2002

15

The Pro-inflammatory Cytokines IL-17A, IL-17F and TNF-alpha Significantly Contribute to the Psoriatic Gene Signature in the Skin

Wendy Trigona, Christopher Morehouse, Christina Strange, Nancy Kohut, Sandrina Phipps, Susan Wilson, Yihong Yao, Barbara White, Lorin Rosko, Bahija Jallal, Wendy White

Journal:

Clinical Immunology

Year:

2009

Language:

english

File:

PDF, 42 KB

english, 2009

16

Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production

Anne P. Liao, Mohammad Salajegheh, Chris Morehouse, Remedios Nazareno, Ronald G. Jubin, Bahija Jallal, Yihong Yao, Steven A. Greenberg

Journal:

Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 775 KB

english, 2010

17

The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation

Ronald J Hill, Sergey Zozulya, Ying-Lin Lu, Kevin Ward, Mikhail Gishizky, Bahija Jallal

Journal:

Experimental Hematology

Year:

2002

Language:

english

File:

PDF, 378 KB

english, 2002

18

Identification of activated cytokine pathways in the blood of systemic lupus erythematosus, myositis, rheumatoid arthritis, and scleroderma patients

Brandon W. HIGGS, Wei ZHU, Laura RICHMAN, David F. FIORENTINO, Steven A. GREENBERG, Bahija JALLAL, Yihong YAO

Journal:

International Journal of Rheumatic Diseases

Year:

2012

Language:

english

File:

PDF, 842 KB

english, 2012

19

Biomarkers for systemic lupus erythematosus

Ronald Herbst, Zheng Liu, Bahija Jallal, Yihong Yao

Journal:

International Journal of Rheumatic Diseases

Year:

2012

Language:

english

File:

PDF, 128 KB

english, 2012

20

Isolation and Functional Characterization of the Human 90K Promoter

Cord Brakebusch, Irmingard Sures, Bahija Jallal, Kevin Mossie, Ornella Fusco, Stefano Iacobelli, Axel Ullrich

Journal:

Year:

1999

Language:

english

File:

PDF, 260 KB

english, 1999

21

A whole genome transcriptional analysis of the early immune response induced by live attenuated and inactivated influenza vaccines in young children

Wei Zhu, Brandon W. Higgs, Chris Morehouse, Katie Streicher, Christopher S. Ambrose, Jennifer Woo, George W. Kemble, Bahija Jallal, Yihong Yao

Journal:

Year:

2010

Language:

english

File:

PDF, 1.53 MB

english, 2010

22

Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus

Fan, Wei, Liang, Dong, Tang, Yuanjia, Qu, Bo, Cui, Huijuan, Luo, Xiaobing, Huang, Xinfang, Chen, Shunle, Higgs, Brandon W., Jallal, Bahija, Yao, Yihong, Harley, John B., Shen, Nan

Journal:

Arthritis & Rheumatism

Year:

2012

Language:

english

File:

PDF, 362 KB

english, 2012

23

Genomic signatures characterize leukocyte infiltration in myositis muscles

Wei Zhu, Katie Streicher, Nan Shen, Brandon W Higgs, Chris Morehouse, Lydia Greenlees, Anthony A Amato, Koustubh Ranade, Laura Richman, David Fiorentino, Bahija Jallal, Steven A Greenberg, Yihong Yao

Journal:

BMC Medical Genomics

Year:

2012

Language:

english

File:

PDF, 981 KB

english, 2012

24

EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner

Xiao, Zhan, Carrasco, Rosa, Kinneer, Krista, Sabol, Darrin, Jallal, Bahija, Coats, Steve, Tice, David A.

Journal:

Cancer Biology & Therapy

Year:

2012

Language:

english

File:

PDF, 830 KB

english, 2012

25

Protein tyrosine phosphatases: their role in insulin action and potential as drug targets

Evans, Joseph L, Jallal, Bahija

Journal:

Expert Opinion on Investigational Drugs

Year:

1999

Language:

english

File:

PDF, 181 KB

english, 1999

26

Developing innovative targeted therapies for China

Journal:

Journal of Translational Medicine

Year:

2012

Language:

english

File:

PDF, 81 KB

english, 2012

27

Endocytosis of the lutropin receptor is mediated by a low affinity binding site

Genty, Nicole, Salesse, Roland, Jallal, Bahija, Garnier, Jean

Journal:

Molecular and Cellular Endocrinology

Year:

1991

Language:

english

File:

PDF, 597 KB

english, 1991

28

Type I interferons in Sjögren's syndrome

Yao, Yihong, Liu, Zheng, Jallal, Bahija, Shen, Nan, Rönnblom, Lars

Journal:

Autoimmunity Reviews

Year:

2013

Language:

english

File:

PDF, 363 KB

english, 2013

29

Formation of Signal Transfer Complexes between Stem Cell and Platelet-Derived Growth Factor Receptors and SH2 Domain Proteins in Vitro

Herbst, Ronald, Shearman, Mark S., Jallal, Bahija, Schlessinger, Joseph, Ullrich, Axel

Journal:

Year:

1995

Language:

english

File:

PDF, 3.59 MB

english, 1995

30

microRNA-mediated regulation of innate immune response in rheumatic diseases

Xiaobing Luo,Koustubh Ranade,Ronel Talker,Bahija Jallal…

Journal:

Arthritis Research & Therapy

Year:

2013

Language:

english

File:

PDF, 308 KB

english, 2013

31

MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D

Georgantas, Robert W., Streicher, Katie, Luo, Xiaobing, Greenlees, Lydia, Zhu, Wei, Liu, Zheng, Brohawn, Philip, Morehouse, Christopher, Higgs, Brandon W., Richman, Laura, Jallal, Bahija, Yao, Yihong,

Journal:

Pigment Cell & Melanoma Research

Year:

2014

Language:

english

File:

PDF, 7.33 MB

english, 2014

32

Monoclonal Antibodies against Luteinizing Hormone Receptor. Immunochemical Characterization of the Receptor*

VUHAI-LUUTHI, MAI THU, JOLIVET, ANDRÉ, JALLAL, BAHIJA, SALESSE, ROLAND, BIDART, JEAN-MICHEL, HOULLIER, ANNE, GUIOCHON-MANTEL, ANNE, GARNIER, JEAN, MILGROM, EDWIN

Journal:

Year:

1990

Language:

english

File:

PDF, 1.31 MB

english, 1990

33

In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage

Zhou, Shiyu, Wang, Yan, Meng, Yao, Xiao, Chunyuan, Liu, Zheng, Brohawn, Philip, Higgs, Brandon W., Jallal, Bahija, Jia, Qian, Qu, Bo, Huang, Xinfang, Tang, Yuanjia, Yao, Yihong, Harley, John B., Shen,

Journal:

Arthritis & Rheumatology

Year:

2016

Language:

english

File:

PDF, 679 KB

english, 2016

34

Type I Interferon Inhibition of MicroRNA-146a Maturation Through Up-Regulation of Monocyte Chemotactic Protein-Induced Protein 1 in Systemic Lupus Erythematosus

Qu, Bo, Cao, Jianchang, Zhang, Feifei, Cui, Huijuan, Teng, Jialin, Li, Jia, Liu, Zheng, Morehouse, Chris, Jallal, Bahija, Tang, Yuanjia, Guo, Qiang, Yao, Yihong, Shen, Nan

Journal:

Arthritis & Rheumatology

Year:

2015

Language:

english

File:

PDF, 398 KB

english, 2015

35

Identification of Cyclin-dependent Kinase 1 as a Novel Regulator of Type 1 Interferon Signaling in Systemic Lupus Erythematosus

Wu, Lingling, Qin, Yuting, Xia, Shiwei, Dai, Min, Han, Xiao, Wu, Yanfang, Zhang, Xiaoyan, Ma, Jianyang, Wang, Yan, Tang, Yuanjia, Liu, Zheng, Zhu, Wei, Jallal, Bahija, Yao, Yihong, Qu, Bo, Shen, Nan

Journal:

Arthritis & Rheumatology

Year:

2015

Language:

english

File:

PDF, 474 KB

english, 2015

36

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Antibodies for the Prevention, Treatment, and Preemption of Infectious Diseases

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 156 KB

english, 2017

37

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Safety Considerations for Biologics

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 481 KB

english, 2017

38

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Human Antibody Structure and Function

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 2.32 MB

english, 2017

39

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Antibodies from Other Species

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 541 KB

english, 2017

40

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Rescue Therapies

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 234 KB

english, 2017

41

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Protein Therapeutics in Respiratory Medicine

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 853 KB

english, 2017

42

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Beyond Antibodies: Engineered Protein Scaffolds for Therapeutic Development

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 1.05 MB

english, 2017

43

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Pharmacokinetics of Therapeutic Proteins

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 432 KB

english, 2017

44

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Human Antibody Discovery Platforms

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 419 KB

english, 2017

45

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Future Horizons and New Target Class Opportunities

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 345 KB

english, 2017

46

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Early Recombinant Protein Therapeutics

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 1.05 MB

english, 2017

47

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Biosimilars

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 581 KB

english, 2017

48

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Antibody-Based Therapeutics in Oncology

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 486 KB

english, 2017

49

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Evolution of Antibody Therapeutics

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 405 KB

english, 2017

50

[Methods and Principles in Medicinal Chemistry] Protein Therapeutics || Bispecifics

Vaughan, Tristan, Osbourn, Jane, Jallal, Bahija

Year:

2017

Language:

english

File:

PDF, 351 KB

english, 2017

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